Tyrosine - gawo lomwe limagwira m'thupi komanso phindu la amino acid

Tyrosine ndi aminocarboxylic acid ofunikira kwambiri omwe amachititsa chidwi kwambiri ndi katabolism ndi anabolism, kuphatikizapo kuphatikiza kwa mapuloteni am'mimba, dopamine, ndi ma neurotransmitters. Kupangidwa kuchokera ku phenylalanine.

Njira yogwiritsira ntchito Tyrosine

Njira yopangira tyrosine ndi C₉H₁₁NO₃, phenylalanine ndi C₉H₁₁NO₂. Tyrosine amapangidwa molingana ndi ziwembu izi:

C₉H₁₁NO₂ + phenylalanine-4-hydroxylase => C₉H₁₁NO₃.

Zotsatira zachilengedwe za tyrosine

Momwe tyrosine imakhudzira thupi komanso momwe imagwirira ntchito:

• imagwira ntchito ngati pulasitiki yopangira melanin, catecholamine mahomoni kapena catecholamines (adrenaline ndi norepinephrine, dopamine, thyroxine, triiodothyronine, L-dioxyphenalalanine), ma neurotransmitters ndi ma neurotransmitters;
• amatenga nawo mbali pakugwira ntchito kwa chithokomiro ndi adrenal gland;
• amakulitsa chipiriro pokumana ndi mavuto, amalimbikitsa kuchira msanga;
• zimathandiza pa ntchito kwa ubongo ndi vestibular zida;
• amavomereza kuchotsedwa;
• chimaonetsa antidepressant kanthu;
• kumawonjezera ndende;
• amatenga nawo mbali pakusinthana;
• kupondereza katemera;
• relieves zizindikiro za matenda premenstrual.

Kugwiritsa ntchito tyrosine pochepetsa thupi

Chifukwa chogwiritsa ntchito mafuta, L-tyrosine imagwiritsidwa ntchito poyanika (kuonda) moyang'aniridwa ndi dokotala wamasewera.

Kuchuluka kwa tyrosine tsiku lililonse

Mlingo wa tyrosine wamasiku onse umachokera magalamu 0.5-1.5, kutengera mawonekedwe amisala ndi malingaliro. Kutenga amino acid kwa miyezi yopitilira 3 motsatizana sikuvomerezeka. Ndi bwino kudya ndi chakudya ndi madzi pang'ono.

Pofuna kupititsa patsogolo chithandizo chamankhwala, tyrosine ikulimbikitsidwa kuti igwiritsidwe ntchito pamodzi ndi methionine ndi mavitamini B6, B1 ndi C.

Kusowa komanso kuchuluka kwa tyrosine, zizindikilo ndi zotsatirapo zake

Kuchulukitsa (hypertyrosinosis kapena hypertyrosinia) kapena kuperewera (hypothyrosinia kapena hypothyrosinosis) kwa amino acid tyrosine m'thupi kumatha kubweretsa zovuta zamagetsi.

Zizindikiro zakuchulukirapo komanso kuchepa kwa tyrosine sizodziwika, zomwe zimapangitsa kuti matendawa akhale ovuta. Mukamapanga matendawa, ndikofunikira kukumbukira zamankhwala am'mbuyo (omwe adasamutsidwa madzulo a matendawa, kumwa mankhwala, kukhala pachakudya).

Zowonjezera

Kuchulukitsa kwa tyrosine kumatha kuwonekera ngati kusalinganika pantchito:

• adrenal zopangitsa;
• chapakati ndi zotumphukira mantha dongosolo;
• chithokomiro (hypothyroidism).

Zoperewera

Kulephera kwa amino acid kumadziwika ndi izi:

• kuchuluka kwa ana;
• kutsika kwa magazi (kuthamanga kwa magazi);
• kuchepa kwa kutentha kwa thupi;
• chopinga cha zolimbitsa thupi ndi malingaliro mwa akulu;
• kufooka kwa minofu;
• kukhumudwa;
• kusinthasintha;
• kunenepa ndi chakudya chokhazikika;
• matenda a miyendo yopuma;
• kutayika tsitsi;
• kuchuluka kugona;
• kuchepa kudya.

Kuperewera kwa Tyrosine kumatha kukhala chifukwa chakusowa kwa chakudya ndi kapangidwe kokwanira ka phenylalanine.

Hypertyrosinosis imadziwika ndi gawo limodzi chifukwa cha kukondoweza kwa kupanga kwa thyroxine (matenda a manda):

• kuchepa kwakukulu kwa kulemera kwa thupi;
• kusokonezeka kwa tulo;
• kuchuluka chisangalalo;
• chizungulire;
• mutu;
• tachycardia;
• Zizindikiro za dyspeptic (kusowa kwa njala, nseru, kutentha pa chifuwa, kusanza, kuchuluka kwa acidity ya madzi am'mimba, hyperacid gastritis kapena chapamimba chilonda kapena 12 duodenal ulcer).

Zotsutsana

Kukonzekera kwa Tyrosine sikuvomerezeka kuti mugwiritse ntchito ndi:

• tsankho kapena thupi lawo siligwirizana ndi zigawo zikuluzikulu za enaake kapena mankhwala;
• matenda a chithokomiro (hyperthyroidism);
• matenda amisala (schizophrenia);
• cholowa cha tyrosinemia;
• chithandizo chamankhwala oletsa MAO (monoamine oxidase);
• Matenda a Parkinson.

Zotsatira zoyipa

Zotsatira zoyipa zimasiyanasiyana ndipo zimatsimikiziridwa osati ndi mawonekedwe amunthu okha, komanso mitundu yosiyanasiyana yamankhwala amthupi omwe aminocarboxylic acid imakhudzidwa. Pachifukwa ichi, pofuna kuwaletsa, tikulimbikitsidwa kuti muyambe kumwa amino acid ndi muyeso wochepa woyang'aniridwa ndi dokotala yemwe akupezekapo.

Zotsatira zoyipa kwambiri zimaphatikizapo arthralgia, kupweteka mutu, kutentha pa chifuwa, ndi mseru.

Kuyanjana

Kusintha kwa zotsatira zamankhwala za tyrosine sikuphatikizidwa mukamagwiritsa ntchito mowa, opiates, steroids kapena zowonjezera masewera. Pachifukwa ichi, ndibwino kuti muwonjezere kuchuluka kwa mankhwala omwe amamwa pang'onopang'ono kuti athe kupatula kuphatikiza kosafunikira ngati kuli kofunikira.

Zakudya zolemera kwambiri za Tyrosine

Amino acid amapezeka munyama ya zinyama, mbalame ndi nsomba, soya, mtedza, zopangira mkaka, nyemba, tirigu, oatmeal, nsomba, zowonjezera chakudya.

Zakudya zamasewera ndi L-tyrosine

L-Tyrosine amapezeka m'mapiritsi a 1100 mg ndi 400 mg, 500 mg kapena 600 mg capsules. Mtsuko 1 wa pulasitiki uli ndi mapiritsi 60, kapena makapisozi 50, 60 kapena 100. Microcrystalline cellulose, aerosil ndi Mg stearate amagwiritsidwa ntchito ngati zodzaza.

Mtengo wa mankhwala kwa makapisozi 60 a 500 mg ali mumtundu wa ma ruble 900-1300.

Ntchito ndi Mlingo

Chofunikira cha tsiku ndi tsiku cha tyrosine kwa wamkulu ndi 25 mg / kg (1.75 g / tsiku). Mlingo umasiyana malinga ndi cholinga chogwiritsa ntchito mankhwalawa (osankhidwa ndi dokotala yemwe akupezekapo).

Ndibwino kuti muchepetse mankhwala ndi tyrosine mu apulo kapena madzi a lalanje.

Onerani kanemayo: Biomolecules Isoelectric point Synthesis u0026 Chemical reactions of Amino acids Part-2 for CSIR-NET (July 2025).