Mu 2010, American Journal of Clinical Nutrition idasindikiza zotsatira zamayesero azachipatala amankhwala angapo okhala ndi carnitine ngati chogwiritsira ntchito. Mwa mankhwala 12, asanu okha ndi omwe adawonetsa chithandizo. Imodzi mwa mankhwala othandiza kwambiri inali Carnicetin.
Mankhwala ozikidwa pa carnitine amagwiritsidwa ntchito ngati mankhwala pochiza matenda obadwa nawo omwe amabwera chifukwa chophatikizira, mankhwala amitsempha ndi zovuta zina.
Pawiri imagwiritsidwa ntchito kwambiri pamasewera chifukwa chakuthupi kwawo kwamafuta. Kuphatikiza apo, carnitine imathandizira kusinthika kwamaselo amtundu wa minofu, kumawonjezera kupirira komanso kumawongolera magwiridwe antchito anzeru muubongo.
Zina zambiri
Carnitine ndimapangidwe opangidwa ndi parenchyma ya impso ndi chiwindi. Katunduyu amatenga gawo lofunikira pamachitidwe azinthu zamthupi - amateteza mayendedwe ndi makutidwe ndi okosijeni a lipids m'ma laboratories amagetsi a cell - mitochondria, amathandizira kapangidwe ka maselo amitsempha, amalepheretsa apoptosis isanakwane (ndiye kuti, kufa kwakanthawi) ndipo amatenga nawo mbali pakukula ndi chitukuko cha thupi. Pali mitundu iwiri ya kapangidwe kake - D ndi L, pomwe L-carnitine yekha ndiye amakhala ndi zochitika zachilengedwe.
Kwa nthawi yoyamba, mankhwalawa adasiyanitsidwa ndi minofu ya asayansi aku Russia koyambirira kwa 19th century. Pambuyo pake, akatswiri adapeza kuti kusowa kolumikizana kumabweretsa kupangika kwamatenda akulu amkati okhala ndi mphamvu zazikulu - mtima, ubongo, impso, chiwindi.
Tulutsani mawonekedwe ndi kapangidwe kake
Mankhwalawa amapezeka ngati makapisozi pamtengo wa zidutswa 60 phukusi limodzi. Chogwiritsira ntchito ndi mawonekedwe a L a carnitine, omwe ndi acetylcarnitine. Mankhwalawa ali ndi zigawo zina zowonjezera - magnesium stearate, microcrystalline cellulose, Aerosil A-300.
Katundu mankhwala
Mtundu wa L wa carnitine umawonetsa kutulutsa kwamafuta acid, ndiye kuti amatenga nawo gawo pa lipid peroxidation mu mitochondria. Chifukwa cha zochita zamagetsi, mphamvu imatulutsidwa ngati ma molekyulu a ATP. Komanso, chinthucho chimasunga kuchuluka kwa acetyl-CoA mkati mwa khungu komanso malo osakanikirana. Zotsatirazi zimakhala ndi njira yotetezera magazi powonjezera kaphatikizidwe ka phospholipids - zigawo zikuluzikulu zama cell cell.
Carnitetine imathandizira kupititsa patsogolo mphamvu zamagetsi zamagetsi pogwiritsa ntchito ma synapses, omwe amathandizanso kuti ubongo ugwire bwino ntchito. Achire Mlingo wa mankhwala kupewa chitukuko cha ischemic kuwonongeka kwa ubongo wa ubongo. Pawuniyi imakhala ndi mphamvu zowonjezeretsanso zoopsa zamankhwala ndi mitundu ina yowonongeka kwamitsempha.
Carnitine, yomwe ndi gawo la mankhwalawa, imathandizira kukumbukira komanso kugwira ntchito kwaubongo, kumawonjezera chidwi ndi kuphunzira. Mankhwalawa awonetsa kuti ndi gawo limodzi la mankhwala ovuta kwa odwala omwe ali ndi matenda a Alzheimer's. Mankhwalawa ndiopindulitsa pakuchita masewera olimbitsa thupi, chifukwa chake amapatsidwa kuti azigwira bwino ntchito ma neuron pokonzekera mayeso.
Zimathandizanso mukamapereka kwa anthu achikulire omwe ali ndi matenda amisala.
Mankhwalawa amalimbikitsa katulutsidwe ndi mphamvu ya amkati serotonin ndipo amakhala ndi mphamvu ya antioxidant. Izi zimakupatsani mwayi wosunga umphumphu wama cell ndi nembanemba zawo.
Acetylcarnitine ikufulumizitsa njira yochepetsera thupi poyambitsa zamadzimadzi ndi zamadzimadzi zimayambira. Kugwiritsa ntchito mankhwalawa pakulimbitsa thupi kumawonjezera kupirira chifukwa cha kuchuluka kwa mapangidwe a mamolekyulu a ATP mu mitochondria.
Chifukwa cha kufanana kwa carnitine ndi mkhalapakati wa acetylcholine, mankhwalawa amayambitsa cholinomimetic mozama ngati kuchepa pang'ono kwa kugunda kwa mtima, kuwonjezeka kwa mgwirizano wa minofu yosalala ya chiberekero, chikhodzodzo, komanso kutsika kwa kupsinjika kwa intraocular.
Zisonyezero
Mankhwalawa amaperekedwa kuti:
- Matenda a Alzheimer's - matenda omwe amadziwika ndi kuwonongeka kofulumira kwa ma neuron muubongo, omwe ali ndi vuto la kuzindikira, matenda amitsempha, amnesia ndi mawonekedwe ena;
- polyneuropathy - kuwonongeka kwa zotumphukira misempha motsutsana ndi matenda a shuga, uchidakwa ndi zina matenda;
- kusokonezeka maganizo kwa okalamba, kukula chifukwa cha kusintha kwa atherosclerotic m'mitsuko ya ubongo.
M'masewera, Karnitsetin imagwiritsidwanso ntchito kukonzanso msanga kwa minofu ndi minofu yamanjenje pakachitika microtraumatization motsutsana ndi kuyesayesa kwamagulu olimbikira. Komanso, mankhwalawa amachulukitsa kupanga mphamvu kwa mitochondria. Izi zimapereka chithandizo chokwanira cha mphamvu zamagetsi osati panthawi yophunzitsira yokha, komanso panthawi yamaganizidwe.
Carnitsetin imagwiritsidwa ntchito ndi othamanga omwe amachita nawo masewera ovuta kuti alowerere pamtima ndikudziwa mayendedwe.
Antioxidant effect imakuthandizani kuti muchepetse ma metabolites ndi poizoni, kupewa kukalamba msanga kwa maselo. Carnicetin imagwiritsidwa ntchito pochepetsa thupi, popeza chinthu chogwira ntchito chimalimbikitsa kutuluka mu depot komanso kufulumira kwa kagayidwe kake ka lipids. Katunduyu amagwiritsidwa ntchito ndi omanga thupi asanachite zisudzo kuti apumulitse thupi.
Zotsutsana
Mankhwalawa amatsutsana ngati atayanjana kapena kusagwirizana ndi zigawozo. Ngati zizindikiro zosafunika zikuwoneka, muyenera kusiya kumwa mankhwala ndi kukaonana ndi dokotala.
Kafukufuku wamankhwala wothandiza komanso chitetezo cha mankhwalawa adachitika m'magulu owunikira, omwe amaphatikizapo anthu azaka zopitilira 18, chifukwa chake kugwiritsa ntchito mankhwalawa kwa ana sikukulimbikitsidwa.
Wachibale contraindications - exacerbation wa gastritis kapena chapamimba chilonda, aimpso kulephera ndi kutchulidwa kuchepa kwa kusefera kwamphamvu kwa zida za glomerular, chithokomiro chokwanira.
Chifukwa cha kuthekera kwa atherogenic, sikulimbikitsidwa kutenga Carnicetin kwa odwala matenda amtima, decompensated myocardial infarction, mtima kulephera, komanso kuthamanga kwa magazi.
Ngati muli ndi kukokana kwa minofu, mankhwala amatha kukulitsa chizindikirocho.
Njira ya makonzedwe ndi mlingo
The kapisozi kutumikiridwa pakamwa. Mlingo woyenera ndi mapiritsi 6-12 patsiku.
Kwa othamanga, pali mitundu yapadera ya kudya - ndikulimbikitsidwa kugwiritsa ntchito mankhwalawa kwa miyezi 1-3 panthawi yogwira, kukonzekera mpikisano ndi zisudzo.
Mlingo wa tsiku ndi tsiku ndi 600-2000 mg, kutengera jenda, zaka komanso mawonekedwe amthupi.
Mphamvu yayikulu kwambiri imawonedwa ndikugwiritsa ntchito Carnicetin ndi zowonjezera mavitamini.
Ndibwino kuti mutenge mankhwalawa mphindi 30-60 musanayambe masewera olimbitsa thupi.
Zotsatira zoyipa
Zotsatira zoyipazi zimalumikizidwa ndi zomwe zimapangitsa kuti munthu asamayende bwino kapena kusagwirizana ndi zomwe zimapangidwira. Nseru, kusanza ndi kutentha pa chifuwa kumatha kuchitika. Ziwonetsero zosafunikira zimatha mankhwala atatha.
Kafukufuku wa 2011 wa Cleveland Clinic adawonetsa kuyanjana kwa carnitine ndikuwonjezera chiwopsezo cha atherosclerosis. Pawiri imagwiritsidwa ntchito ndi mitundu ina ya mabakiteriya opindulitsa monga gawo lapansi la kaphatikizidwe ka chinthu china chokhala ndi moyo waufupi - trimethylamine, chomwe chimasandulika kukhala trimethylamine oxide - chimodzi mwazinthu zamphamvu kwambiri za atherogenic.
Bongo
Milandu ya mankhwala osokoneza bongo sinazindikiridwe, komabe, pali umboni woti tulo titha kuyamba pomwe mankhwalawa amwedwa kwambiri.
Kupitilira mlingo wovomerezeka wovomerezeka nthawi zambiri kumawonetsedwa ndi kupweteka kwakanthawi m'dera la epigastric, kusokonezeka kwa chopondapo, nseru, kusanza, ndi mpweya woipa.
Malangizo apadera
Kuperekera munthawi yomweyo Carnicetin ndi zakumwa zoledzeretsa sikuvomerezeka, chifukwa mowa wa ethyl umachepetsa mphamvu ya mankhwala.
Kuyanjana kwa mankhwala
Kuyanjana kwa Carnicetin ndi mankhwala ena sikunatchulidwe.
Analogs
Zofanana za Karnitetin ndi izi:
- Zokometsera;
- Acetylcarnitine.
Migwirizano ndi zokwaniritsa zosunga
Ndibwino kuti musunge mankhwalawa patali ndi ana. Pewani kuwala kwa dzuwa. Kutentha kwakukulu kosungira kumachokera madigiri 15 mpaka 25. Alumali moyo ndi chaka chimodzi.
Malamulo operekera ku pharmacies
Kwa 2018, mankhwalawa ndi mankhwala akuchipatala.
Mtengo m'masitolo
Mtengo wapakati wa paketi ya Karnitetin m'masitolo amasiyana ma ruble 510 mpaka 580. Sikoyenera kugula mankhwalawa pamanja, malinga ndi zotsatsa pa Avito, ndi zina zambiri. Gulani kokha kwa omwe amagawa ovomerezeka.
